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McGill University

Royal Victoria Hospital

McGill University Health Centre

Department of Kinesiology and Physical Education- McGill University

Meakins-Christie Laboratories

McGill University Health Centre Research Institute


Selected Publications

  1. Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan N, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT. Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol. 2016 Sep 13. doi: 10.1113/JP272487. PubMed

  2. Aare S, Spendiff S, Vuda M, Elkrief D, Perez A, Wu Q, Mayaki D, Hussain SN, Hettwer S, Hepple RT. Failed reinnervation in aging skeletal muscle. Skelet Muscle. 2016 Sep 1;6(1):29. doi: 10.1186/s13395-016-0101-y. PubMed

  3. Gouspillou G, Hepple RT. Editorial: Mitochondria in Skeletal Muscle Health, Aging and Diseases. Front Physiol. 2016 Oct 6;7:446. doi: 10.3389/fphys.2016.00446 Frontiers

  4. Cartee GD, Hepple RT, Bamman MM, Zierath JR. Exercise Promotes Healthy Aging of Skeletal Muscle. Cell Metab. 2016 Jun 14;23(6):1034-47. doi: 10.1016/j.cmet.2016.05.007. PubMed

  5. Hepple RT. Impact of aging on mitochondrial function in cardiac and skeletal muscle. Free Radic Biol Med. 2016 Mar 24. pii: S0891-5849(16)00123-4. doi: 10.1016/j.freeradbiomed.2016.03.017. PubMed

  6. Power GA, Allen MD, Gilmore KJ, Stashuk DW, Doherty TJ, Hepple RT, Taivassalo T, Rice CL. Motor unit number and transmission stability in octogenarian world class athletes: Can age-related deficits be outrun? J Appl Physiol (1985). 2016 Mar 24:jap.00149.2016. doi: 10.1152/japplphysiol.00149.2016. PubMed

  7. Konokhova Y, Spendiff S, Jagoe RT, Aare S, Kapchinsky S, MacMillan NJ, Rozakis P, Picard M, Aubertin-Leheudre M, Pion CH, Bourbeau J, Hepple RT, Taivassalo T. Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle. Skelet Muscle. 2016 Feb 18;6:10. doi: 10.1186/s13395-016-0083-9. eCollection 2016. PubMed

  8. Power GA, Minozzo FC, Spendiff S, Filion ME, Konokhova Y, Purves-Smith MF, Pion C, Aubertin-Leheudre M, Morais JA, Herzog W, Hepple RT, Taivassalo T, Rassier DE. Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older masters athletes. Skelet Muscle. 2016 Feb 18;6:10. doi: 10.1186/s13395-016-0083-9. eCollection 2016. PubMed

  9. Hepple RT, Rice CL. Innervation and neuromuscular control in ageing skeletal muscle. J Physiol. 2016 Apr 15;594(8):1965-78. doi: 10.1113/JP270561. Epub 2015 Dec 21. PubMed

  10. Neufer PD, Bamman MM, Muoio DM, Bouchard C, Cooper DM, Goodpaster BH, Booth FW, Kohrt WM, Gerszten RE, Mattson MP, Hepple RT, Kraus WE, Reid MB, Bodine SC, Jakicic JM, Fleg JL, Williams JP, Joseph L, Evans M, Maruvada P, Rodgers M, Roary M, Boyce AT, Drugan JK, Koenig JI, Ingraham RH, Krotoski D, Garcia-Cazarin M, McGowan JA, Laughlin MR. Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits. Cell Metab. 2015 Jul 7;22(1):4-11. doi: 10.1016/j.cmet.2015.05.011. Epub 2015 Jun 11. Review. PMID: 26073496 PubMed

  11. Gouspillou G, Scheede-Bergdahl C, Spendiff S, Vuda M, Meehan B, Mlynarski H, Archer-Lahlou E, Sgarioto N, Purves-Smith FM, Konokhova Y, Rak J, Chevalier S, Taivassalo T, Hepple RT, Jagoe RT. Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle. Sci Rep. 2015 Mar 3;5:8717. doi: 10.1038/srep08717. PMID: 25732599 PubMed

  12. F.M. Purves-Smith , N. Sgarioto , and R.T. Hepple . Fiber typing in aging muscle. Exercise and Sport Sciences Reviews 42(2): 45-52, 2014. PMID: 24508741 PubMed

  13. G. Gouspillou , N. Sgarioto , B. Norris , S. Barbat-Artigas, M. Aubertin-Leuhedre, J.A. Morais, Y. Burelle, T.Taivassalo, and R.T. Hepple . The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies significantly between rodent models and humans. PLoS One 9(8): e103044, 2014 . PMID: 25121500 PubMed

  14. R.T. Hepple . Mitochondrial Involvement and Impact in Aging Skeletal Muscle. Frontiers in Aging Neuroscience 6: 211, 2014. frontiers

  15. Gouspillou G, Sgarioto N, Kapchinsky S, Purves-Smith F, Norris B, Pion CH, Barbat-Artigas S, Lemieux F, Taivassalo T, Morais JA, Aubertin-Leheudre M, Hepple RT. Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans. FASEB J. 2014 Apr;28(4):1621-33. doi: 10.1096/fj.13-242750. FASEB

  16. G. Gouspillou , M. Picard , R. Godin, Y. Burelle and R.T. Hepple . Role of PGC-1α in denervation-induced atrophy in aged muscle: facts and hypotheses. Longevity and Lifespan 2: 13, 2013 (doi: 10.1186/2046-2395-2-13 ). Longevity and Healthspan

  17. Wright KJ, Thomas MM, Betik AC, Belke D, Hepple RT. Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats. Exp Gerontol. 2014 Feb;50:9-18. doi: 10.1016/j.exger.2013.11.006. Epub 2013 Nov 23. Pubmed
  18. G. Gouspillou and R.T. Hepple . Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion. Experimental Gerontology (Invited Review) 48(10): 1075-84, 2013. PMID23523973 PubMed

  19. M. Mofarrahi, Y. Guo, J.A. Haspel, A.M.K. Choi, E.C. Davis, G. Gouspillou , R.T. Hepple , R. Godin, Y. Burelle, and S.N. Hussain. Autophagic flux and oxidative capacity of skeletal muscles during acute starvation. Autophagy (In Press). PMID: 23955121 PubMed

  20. Picard M, Wright KJ, Ritchie D, Thomas MM, Hepple RT. Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium. PLoS One 7(8): e43003, 2012. PubMed

  21. Purves-Smith FM, Solbak NM, Rowan SL, Hepple RT. Severe atrophy of slow myofibers in aging muscle is concealed by myosin heavy chain co-expression. Exp Gerontol 47(12): 913-8, 2012. PubMed

  22. S.L. Rowan, K.A. Rygiel, F.M. Purves-Smith, N.M. Solbak, D.M. Turnbull and R.T. Hepple. Denervation causes fiber atrophy and myosin heavy chain co-expression in senescent skeletal muscle. PLoS One 7(1): e29082, 2012. PubMed

  23. M. Picard, R.T. Hepple, and Y. Burelle. Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function. American Journal of Physiology Cell Physiology. 302(4): C629-641, 2012. PubMed

  24. M. Picard, D. Ritchie, M.M. Thomas, K.J. Wright, and R.T. Hepple. Alterations in Intrinsic Mitochondrial Function with Aging are Fiber Type-specific and do not Explain Differential Atrophy between Muscles. Aging Cell 10(6): 1047-1055, 2011. PubMed

  25. M.M. Thomas, C. Vigna, A.C. Betik, A.R. Tupling, and R.T. Hepple. Cardiac calcium pump inactivation and nitrosylation in senescent rat myocardium is not attenuated by long-term treadmill training. Experimental Gerontology 46(10): 803-810, 2011. PubMed

  26. M. Picard, T. Taivassalo, G. Gouspillou, and R.T. Hepple. Mitochondria: Isolation, Structure, and Function. Journal of Physiology 589.18: 4413-4421, 2011. PubMed

  27. J. Murias, J. Kowalchuk, D. Ritchie, R.T. Hepple, T. Doherty and D. Paterson. Similar adaptations in capillarization and citrate synthase activity in response to endurance training in older and young men. Journal of Gerontology Biological Sciences 66(9): 957-964, 2011. PubMed

  28. S.L. Rowan, F.M. Purves-Smith, N.M. Solbak, and R.T. Hepple. Accumulation of Severely Atrophic Myofibers Marks the Acceleration of Sarcopenia in Slow and Fast Twitch Muscles. Experimental Gerontology 46(8): 660-669, 2011. PubMed

  29. M. Picard, T. Taivassalo, D. Ritchie, K.J. Wright, M.M. Thomas, C. Romestaing, and R.T. Hepple. Mitochondrial structure and function are disrupted by standard isolation methods. PLoS One 6(3): e18317, 2011. PubMed

  30. C. Tweedie, C. Romestaing, Y. Burelle, A. Safdar, M.A. Tarnopolsky, S.L. Britton, L. Koch, and R.T. Hepple. Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. American Journal of Physiology Regulatory Integrative and Comparative Physiology 300(3): R544-553, 2011. PubMed

  31. M. Picard, D. Ritchie, K.J. Wright, M.M. Thomas, S.L. Rowan, T. Taivassalo, and R.T. Hepple. Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers. Aging Cell 9(6): 1032-1046, 2010. PubMed

  32. M.M. Thomas, W. Khan, A.C. Betik, K.J. Wright, and R.T. Hepple. Initiating exercise training in late middle age minimally protects muscle contractile function and increases myocyte oxidative damage in senescent rats. Experimental Gerontology 45(11): 856-867, 2010. PubMed

  33. E.E. Carter, M.M. Thomas, T. Murynka, S.L. Rowan, K.J. Wright, E. Huba, and R.T.Hepple. Slow twitch soleus muscle is not protected from sarcopenia in senescent rats. Experimental Gerontology 45(9): 662-670, 2010. PubMed

  34. M.M. Thomas, C. Vigna, A.C. Betik, A.R. Tupling, and R.T. Hepple. Initiating treadmill training in late middle age offers modest adaptations in Ca2+ handling but enhances oxidative damage in senescent rat skeletal muscle. American Journal of Physiology Regulatory Integrative and Comparative Physiology 298(5): R1269-1278, 2010. PubMed

  35. A.C. Betik, M.M. Thomas, K.J. Wright, C.D. Riel and R.T. Hepple. Exercise training from late middle age to senescence does not attenuate the declines in skeletal muscle aerobic function. American Journal of Physiology Regulatory Integrative and Comparative Physiology 297(3): R744-755, 2009. PubMed

  36. R.T. Hepple, M. Qin, H. Nakamoto, and S. Goto. Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia. American Journal of Physiology Regulatory Integrative and Comparative Physiology 295(4): R1231-1237, 2008. PubMed

  37. A.C. Betik, D.J. Baker, D.J. Krause, M.J. McConkey, and R.T. Hepple. Exercise training in late middle aged male F344BN rats improves skeletal muscle aerobic function. Experimental Physiology 93.7: 863-871, 2008. PubMed

  38. D.J. Baker and R.T. Hepple. Elevated caspase and AIF signaling correlates temporally with progression of sarcopenia in male F344BN rats. Experimental Gerontology 41: 1149-1156, 2006. PubMed

  39. D.J. Baker, A.C. Betik, D.J. Krause, and R.T. Hepple. No decline in skeletal muscle oxidative capacity with aging in long-term caloric restricted rats: effects are independent of mtDNA integrity. Journals of Gerontology Biological Sciences 61A: 675-684, 2006. PubMed

  40. R.T. Hepple, D.J. Baker, M. McConkey, T. Murynka and R. Norris. Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles. Rejuvenation Research 9(2): 219-222, 2006. PubMed

  41. R.T. Hepple, D.J. Baker, J.J. Kaczor and D.J. Krause. Long-term caloric restriction abrogates the age-related decline in skeletal muscle aerobic function. The FASEB Journal 19(10): 1320-1322, 2005. PubMed

  42. R.T. Hepple, J.L. Hagen, D.J. Krause, and D.J. Baker. Skeletal muscle aging in F344BN F1-hybrid rats: II. Improved contractile economy in senescence helps compensate for reduced ATPgenerating capacity. Journals of Gerontology Biological Sciences 59A(11): 1111-1119, 2004. PubMed

  43. J.L. Hagen, D.J. Krause, D.J. Baker, M. Fu, M.A. Tarnopolsky, and R.T. Hepple. Skeletal muscle aging in F344BN F1-hybrid rats: I. Mitochondrial dysfunction contributes to the age-associated reduction in VO2max. Journals of Gerontology Biological Sciences 59A(11): 1099-1110, 2004. PubMed

  44. R.T. Hepple and J.E. Vogell. Anatomic capillarization is maintained in relative excess of fiber oxidative capacity in some skeletal muscles of late middle aged rats. Journal of Applied Physiology 96: 2257-2264, 2004. PubMed

  45. R.T. Hepple, K.D. Ross, and A.B. Rempfer. Fiber atrophy and hypertrophy in skeletalmuscles of late middle aged Fischer 344 X Brown Norway F1-hybrid rats. Journals of Gerontology Biological Sciences 59A(2): 108-117, 2004. PubMed

  46. R.T. Hepple, J.L. Hagen, D.J. Krause, and C.C. Jackson. Aerobic power declines with aging in rat skeletal muscles perfused at matched convective O2 delivery. Journal of Applied Physiology 94:744-751, 2003. PubMed